Uncle Buck
Buck Russell, a lovable but slovenly bachelor, suddenly becomes the temporary caretaker of his nephew and nieces after a family emergency. His freewheeling attitude soon causes tension with his older niece Tia, loyal girlfriend Chanice and just about everyone else who crosses his path.
John Candy
Buck Russell
Jean Louisa Kelly
Tia Russell
Gaby Hoffmann
Maizy Russell
Macaulay Culkin
Miles Russell
Amy Madigan
Chanice Kobolowski
Elaine Bromka
Cindy Russell
Garrett M. Brown
Bob Russell
Laurie Metcalf
Marcie Dahlgren-Frost
Jay Underwood
Bug
Brian Tarantina
E. Roger Coswell
Mike Starr
Pooter-the-Clown
Suzanne Shepherd
Mrs. Hogarth
William Windom
Mr. Hatfield (voice)
Dennis Cockrum
Pal
Joel Robinson
Miles' Friend #1
Colin Baumgartner
Miles' Friend #2
Erik Whipple
Miles' Friend #3
Mark Rosenthal
Party Boy #1
Doug von Nessen
Party Boy #2
Wayne Kneeland
Party Boy #3
Gigi Casler
Party Girl in Bedroom
LaVerne Anderson
Party Girl #1
Gina Doctor
Party Girl #2
Rachel Thompson Perrine
Party Girl #3
Ron Payne
Maizy's Teacher
Jane Vickerilla
Teacher
Kyle Lewis Eastman
School Child
Dana Taylor
School Child
Jennifer Kane
School Child
Christen Loftis
School Child
Genae Affrunti
School Child
Anna Chlumsky
School Child
Patricia Arquette
Additional Voices (voice)
Jack Blessing
Additional Voices (voice)
Devon Odessa
Additional Voices (voice)
Ryan Goldstein
School Child (uncredited)
Arnold F. Turner
Additional Voices (voice)